Muscle stem cell aging: identifying ways to induce tissue rejuvenation.
Author: Sousa-Victor P1, Neves J2, Muñoz-Cánoves P3
Affiliation:
1Instituto de Medicina Molecular (iMM), Faculdade de Medicina, Universidade de Lisboa, Lisbon, 1649-028, Portugal. Electronic address: psvictor@medicina.ulisboa.pt.
2Instituto de Medicina Molecular (iMM), Faculdade de Medicina, Universidade de Lisboa, Lisbon, 1649-028, Portugal. Electronic address: joana.neves@medicina.ulisboa.pt.
3Department of Experimental & Health Sciences, University Pompeu Fabra (UPF), CIBERNED, ICREA, 08003, Barcelona, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28019, Madrid, Spain. Electronic address: pura.munoz@upf.edu.
Conference/Journal: Mech Ageing Dev.
Date published: 2020 Apr 17
Other:
Volume ID: 111246 , Special Notes: doi: 10.1016/j.mad.2020.111246. [Epub ahead of print] , Word Count: 178
Aging is characterized by the functional and regenerative decline of tissues and organs. This regenerative decline is a consequence of the numerical and functional loss of adult stem cells, which are the corner stone of tissue homeostasis and repair. A palpable example of this decline is provided by skeletal muscle, a specialized tissue composed of postmitotic myofibers that contract to generate force. Skeletal muscle stem cells (satellite cells) are long-lived and support muscle regeneration throughout life, but at advanced age they fail for largely undefined reasons. Here, we discuss recent advances in the understanding of how satellite cells integrate diverse intrinsic and extrinsic processes to ensure optimal homeostatic function and how this integration is perturbed during aging, causing regenerative failure. With this increased understanding, it is now feasible to design and test interventions that delay satellite cell aging. We discuss the exciting new therapeutic potential of integrating and combining distinct anti-aging strategies for regenerative medicine.
Copyright © 2020. Published by Elsevier B.V.
KEYWORDS: aging; regeneration; rejuvenation; sarcopenia; satellite cell; skeletal muscle; stem cell; tissue repair
PMID: 32311419 DOI: 10.1016/j.mad.2020.111246
BACK
