A Review of Exercise as Medicine in Cardiovascular Disease: Pathology and Mechanism.

Author: Gronek P1, Wielinski D2, Cyganski P3, Rynkiewicz A3, Zając A4, Maszczyk A5, Gronek J1, Podstawski R6, Czarny W7, Balko S8, Ct Clark C9, Celka R1
11Laboratory of Genetics, Department of Dance and Gymnastics, Poznań University of Physical Education, Poznań, Poland.
22 Department of Anthropology and Biometry, Poznań University of Physical Education, Poznań, Poland.
33Department of Cardiology and Cardiosurgery, Ist Cardiology Clinic, City Hospital in Olsztyn, University of Warmia and Mazury in Olsztyn, Poland.
44Department of Sports Training, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
55Department of Methodology and Statistics, The Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland.
66Department of Physical Education and Sport, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
77Department of Human Sciences, University of Rzeszow, Rzeszów, Poland.
88Department of Physical Education and Sport, Faculty of Education, Jan Evangelista Purkyne University in Usti nad Labem, Czech Republic.
99School of Life Sciences, Coventry University, Coventry, CV1 5FB, United Kingdom.
Conference/Journal: Aging Dis.
Date published: 2020 Mar 9
Other: Volume ID: 11 , Issue ID: 2 , Pages: 327-340 , Special Notes: doi: 10.14336/AD.2019.0516. eCollection 2020 Apr. , Word Count: 219

Background: Physical inactivity and resultant lower energy expenditure contribute unequivocally to cardiovascular diseases, such as coronary artery disease and stroke, which are considered major causes of disability and mortality worldwide.

Aim: The aim of the study was to investigate the influence of physical activity (PA) and exercise on different aspects of health - genetics, endothelium function, blood pressure, lipid concentrations, glucose intolerance, thrombosis, and self - satisfaction. Materials and.

Methods: In this article, we conducted a narrative review of the influence PA and exercise have on the cardiovascular system, risk factors of cardiovascular diseases, searching the online databases; Web of Science, PubMed and Google Scholar, and, subsequently, discuss possible mechanisms of this action.

Results and Discussion: Based on our narrative review of literature, discussed the effects of PA on telomere length, nitric oxide synthesis, thrombosis risk, blood pressure, serum glucose, cholesterol and triglycerides levels, and indicated possible mechanisms by which physical training may lead to improvement in chronic cardiovascular diseases.

Conclusion: PA is effective for the improvement of exercise tolerance, lipid concentrations, blood pressure, it may also reduce the serum glucose level and risk of thrombosis, thus should be advocated concomitant to, or in some cases instead of, traditional drug-therapy.

Copyright: © 2020 Gronek et al.

KEYWORDS: aging; cardiovascular disease; longevity; physical activity; public health problem

PMID: 32257545 PMCID: PMC7069454 DOI: 10.14336/AD.2019.0516