Mindfulness interventions for rheumatoid arthritis: A systematic review and meta-analysis.

Author: Zhou B1, Wang G2, Hong Y3, Xu S1, Wang J3, Yu H1, Liu Y4, Yu L5
1International School of Nursing, Huangshan Vocational Technical College, Huangshan, China.
2Department of General Surgery, Jiangsu Province Hospital of TCM, China.
3Department of Medicine, Huangshan Vocational Technical College, Huangshan, China.
4Department of Nursing, Jinling Hospital, Nanjing University School of Medicine, China.
5Department of Medicine, Huangshan Vocational Technical College, Huangshan, China. Electronic address: 1056879093@qq.com.
Conference/Journal: Complement Ther Clin Pract.
Date published: 2020 Jan 11
Other: Volume ID: 39 , Pages: 101088 , Special Notes: doi: 10.1016/j.ctcp.2020.101088. [Epub ahead of print] , Word Count: 214

OBJECTIVES: To explore the effect of mindfulness interventions in improving outcomes for patients with rheumatoid arthritis.

METHODS: Following the collective strategy of Cochrane Collaborative Group, the Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and Wanfang Database were searched from the establishment of databases to September 2019. Reference lists were searched for additional studies. Risk of bias was assessed using Revman 5.3. Disagreement was resolved by discussion.

RESULTS: A total of 6 RCTs were included, including 337 patients. The results showed that the improvement of pain intensity in mindfulness group after intervention was better than that in the control group, and the difference was significant [WMD = 0.65, 95% CI (-1.11, - 0.18), P = 0.006]. There were significant differences in depression between the two groups [SMD = 0.47, 95% CI (- 0.86, - 0.07), P = 0.02]. The results showed that there were significant differences in DSA28 between the two groups [WMD = -0.29,95% CI (- 0.38, - 0.19), P <0.00001]. The results showed that there were no significant differences in anxiety and CPR between the two groups.

CONCLUSION: mindfulness interventions can significantly improve pain intensity, depression, and symptoms in patients with rheumatoid arthritis compared with conventional therapy. But the result still needs to be confirmed by more high-quality, large-sample randomized controlled trials.

Copyright © 2020 Elsevier Ltd. All rights reserved.

KEYWORDS: Anxiety; Depression; Meta-analysis; Mindfulness; Rheumatoid arthritis

PMID: 31957665 DOI: 10.1016/j.ctcp.2020.101088