An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure.
Author: Redwine LS1, Pung MA2, Wilson K3, Bangen KJ4, Delano-Wood L4, Hurwitz B5
Affiliation:
1Department of Psychiatry, University of California, San Diego, CA, USA; College of Nursing, University of South Florida, Tampa, FL, USA. Electronic address: lredwine@usf.edu.
2Department of Family Medicine and Public Health, University of California, San Diego, CA, USA; College of Nursing, University of South Florida, Tampa, FL, USA.
3Department of Family Medicine and Public Health, University of California, San Diego, CA, USA.
4Department of Psychiatry, University of California, San Diego, CA, USA.
5Psychology Department, University of Miami, USA.
Conference/Journal: J Psychosom Res.
Date published: 2019 Nov 26
Other:
Volume ID: 128 , Pages: 109883 , Special Notes: doi: 10.1016/j.jpsychores.2019.109883. [Epub ahead of print] , Word Count: 231
OBJECTIVE: Almost half of patients with heart failure (HF) have cognitive impairment. While exercise relates to better cognitive health, a hallmark of HF is exercise intolerance. The study objective was to explore whether light-to-moderate exercise improves cognitive function in patients with HF.
METHODS: This was an exploratory parallel design study of 69 patients with symptomatic HF (mean age = 65, SD = 10), recruited from VA and University of California, San Diego Healthcare Systems. Participants were randomized to Tai Chi (TC) (n = 24), resistance band (RB) exercise (n = 22) or treatment as usual (TAU) (n = 23). The primary outcome was change in Montreal Cognitive Assessment (MoCA) scores. We further explored if changes in Beck Depression Inventory - IA (BDI-IA) scores or inflammation biomarkers, CRP, TNFα and IL-6 related to altered cognitive function.
RESULTS: There was a fixed effect of group for MoCA scores changes (F = 8.07, p = .001). TC and RB groups had greater MoCA score increases versus TAU, but no differences were found between TC and RB. Depression symptom changes predicted altered MoCA scores (ΔR2 = 0.15, Β = -0.413, p = .001). However, group did not interact with depression symptom levels for MoCA alterations (p = .392). Changes in CRP levels predicted MoCA scores (ΔR2 = 0.078, Β = -0.283, p = .01), but group did not interact with CRP levels for MoCA alterations (p = .689).
CONCLUSIONS: Light-to-moderate exercises, TC and RB may improve cognitive function. However, the mechanisms remain unclear. ClinicalTrials.gov: NCT01625819.
Copyright © 2019 Elsevier Inc. All rights reserved.
PMID: 31786338 DOI: 10.1016/j.jpsychores.2019.109883
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