Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome.

Author: Zhu GY1, Geng XY2,3, Zhang RL2,3, Chen YC1, Liu YY1, Wang SY2,3, Zhang JG1,4
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
2Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
3Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.
4Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Conference/Journal: Brain Behav.
Date published: 2019 Oct 24
Other: Volume ID: e01450 , Special Notes: doi: 10.1002/brb3.1450. [Epub ahead of print] , Word Count: 256

INTRODUCTION: Previous studies found subthalamic nucleus deep brain stimulation (STN-DBS) has clinical effect on Parkinson's disease, dystonia, and obsessive compulsive disorder. It is noteworthy that only a few studies report the STN-DBS for Tourette's syndrome (TS). Globus pallidus interna (GPi)-DBS is the one of the most common targets for TS. So, this paper aims to investigate the neural oscillations in STN and GPi as well as the DBS effect between these two targets in same patients.

METHODS: The local field potentials (LFPs) were simultaneously recorded from the bilateral GPi and STN in four patients with TS. The LFPs were decomposed into neural oscillations, and the frequency and time-frequency characteristics of the neural oscillations were analyzed across the conditions of resting, poststimulation, and movement.

RESULTS: No difference of resting LFP was found between the two targets. The poststimulation period spectral power revealed the high beta and gamma oscillations were recovered after GPi-DBS but remained attenuated after STN-DBS. The STN beta oscillation has fewer changes during tics than voluntary movement, and the gamma oscillation was elevated when the tics appeared.

CONCLUSION: The high beta and gamma oscillations in GPi restored after GPi-DBS, but not STN-DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN-DBS due to the influence on the hyper-direct pathway but not GPi-DBS.

© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

KEYWORDS: Tourette's syndrome; deep brain stimulation; globus pallidus interna; local field potential; subthalamic nucleus

PMID: 31647199 DOI: 10.1002/brb3.1450