Stress Reduction in the Prevention of Left Ventricular Hypertrophy: A Randomized Controlled Trial of Transcendental Meditation and Health Education in Hypertensive African Americans.

Author: Schneider RH1, Myers HF2, Marwaha K1, Rainforth MA1, Salerno JW1, Nidich SI1, Gaylord-King C1, Alexander CN1, Norris KC3
Affiliation:
1Institute for Natural Medicine and Prevention, Maharishi University of Management, Fairfield, IA, USA.
2Vanderbilt University, Vanderbilt Place, Nashville, Tennessee, USA.
3David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Conference/Journal: Ethn Dis.
Date published: 2019 Oct 17
Other: Volume ID: 29 , Issue ID: 4 , Pages: 577-586 , Special Notes: doi: 10.18865/ed.29.4.577. eCollection 2019 Fall. , Word Count: 280


Background: African Americans have disproportionately high rates of cardiovascular disease (CVD). Left ventricular hypertrophy (LVH) is an independent risk factor for CVD and may contribute to this disparity. Psychological stress contributes to LVH in African Americans and other populations.

Objective: This study evaluated the effects of stress reduction with the Transcendental Meditation (TM) technique on preventing LVH in African American adults with hypertension.

Setting: Martin Luther King Hospital - Charles R. Drew University of Medicine and Science, Los Angeles, CA.

Method: In this trial, 85 African American adults (average 52.8 years) were randomly assigned to either TM program or health education (HE) control group and completed posttesting. Participants were tested at baseline and after six months for left ventricular mass index (LVMI) by M-mode echocardiography, blood pressure, psychosocial stress and behavioral factors. Change in outcomes was analyzed between groups by ANCOVA and within groups by paired t-test.

Results: The TM group had significantly lower LVMI compared with the HE group (-7.55gm/m2, 95% CI -14.78 to -.34 gm/m2, P=.040). Both interventions showed significant within group reductions in BP, (SBP/DBP changes for TM: -5/ -3 mm Hg, and for HE: -7/-6 mm Hg, P=.028 to <.001) although between group changes were not significant. In addition, both groups showed significant reductions in anger (P=.002 to .001). There were no other changes in lifestyle factors.

Conclusions: These findings indicate that stress reduction with TM was effective in preventing LVMI progression and thus may prevent LVH and associated CVD in high-risk African American patients.

Copyright © 2019, Ethnicity & Disease, Inc.

KEYWORDS: Cardiovascular Disease; Health Disparity; Left Ventricular Hypertrophy; Left Ventricular Mass Index; Stress Reduction; Transcendental Meditation

PMID: 31641325 PMCID: PMC6802172 [Available on 2020-04-17] DOI: 10.18865/ed.29.4.577

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