An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation.
Author: Caravaca AS1, Gallina AL1, Tarnawski L1, Tracey KJ2, Pavlov VA2, Levine YA3, Olofsson PS1,2
Affiliation:
1Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
2Center for Biomedical Science and Bioelectronic Medicine, The Feinstein Institute for Medical Research, Manhasset, NY, United States.
3Setpoint Medical, Inc., Valencia, CA, United States.
Conference/Journal: Front Neurosci.
Date published: 2019 Aug 27
Other:
Volume ID: 13 , Pages: 877 , Special Notes: doi: 10.3389/fnins.2019.00877. eCollection 2019. , Word Count: 133
Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation (VNS) in treatment of rheumatoid arthritis and Crohn's disease suggest that there is a therapeutic potential of electrical VNS in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical VNS in a range of experimental settings and available genetic mouse models of disease. Here, we describe a method for electrical VNS in experimental inflammation in mice.
KEYWORDS: Bioelectronic Medicine; inflammation; inflammatory reflex; neural control; neural reflex; peripheral nerve; vagus nerve stimulation
PMID: 31551672 PMCID: PMC6736627 DOI: 10.3389/fnins.2019.00877
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