Modulatory effect of International Standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI.

Author: Chung WY1, Liu SY2, Gao JC3, Jiang YJ4, Zhang J2, Qu SS5, Zhang JP5, Tan XL6, Chen JQ3, Wang SX5
Author Information:
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province; School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
2Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
3Department of Rehabilitation Medicine, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
4Department of Rehabilitation Medicine, Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China.
5School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province, China.
6Department of Medical Image, Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China.
Conference/Journal: Neural Regen Res.
Date published: 2019 Dec
Other: Volume ID: 14 , Issue ID: 12 , Pages: 2126-2131 , Special Notes: doi: 10.4103/1673-5374.262590. , Word Count: 231


The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women; 50-70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043).

PMID: 31397351 DOI: 10.4103/1673-5374.262590

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