Modulatory effects of different exercise modalities on the functional connectivity of the periaqueductal grey and ventral tegmental area in patients with knee osteoarthritis: a randomised multimodal magnetic resonance imaging study.

Author: Liu J1, Chen L2, Chen X3, Hu K4, Tu Y4, Lin M4, Huang J4, Liu W4, Wu J4, Qiu Z4, Zhu J4, Li M5, Park J6, Wilson G6, Lang C6, Xie G4, Tao J7, Kong J6
Author Information:
1National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
2College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China; Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
3Department of Rehabilitation Psychology and Special Education, University of Wisconsin-Madison, Madison, WI, USA.
4College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
5Affiliated Rehabilitation Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
6Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
7College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China. Electronic address: taojing01@163.com.
Conference/Journal: Br J Anaesth.
Date published: 2019 Aug 5
Other: Pages: S0007-0912(19)30506-9 , Special Notes: doi: 10.1016/j.bja.2019.06.017. [Epub ahead of print] , Word Count: 286


BACKGROUND: Knee osteoarthritis is a prevalent disorder with unsatisfactory treatment options. Both physical and mindful exercises may be able to relieve its pain symptoms. We compared the modulatory effects of different exercise modalities on the periaqueductal grey (PAG) and ventral tegmental area (VTA), which play important roles in descending opioidergic pathways and reward/motivation systems in patients with knee osteoarthritis.

METHODS: We recruited and randomised 140 patients into Tai Chi, Baduanjin, stationary cycling, and health education control groups for 12 weeks. Knee injury and Osteoarthritis Outcome Score (KOOS), functional and structural MRI, and blood biomarkers were measured at the beginning and end of the experiment. We used the PAG and VTA as seeds in resting-state functional connectivity (rsFC) analysis.

RESULTS: Compared with the control group: (i) all exercises significantly increased KOOS pain sub-scores (pain reduction) and serum programmed death 1 (PD-1) concentrations as well as decreased serum interferon gamma concentrations; (ii) all exercises decreased right PAG rsFC with the medial orbital prefrontal cortex, and the decreased rsFC was associated with improvements in knee pain; and (iii) grey matter volume in the medial orbital prefrontal cortex was significantly increased in all exercise groups. There was also significantly decreased rsFC between the left VTA and the medial orbital prefrontal cortex in the Tai Chi and Baduanjin groups.

CONCLUSIONS: Exercise can simultaneously modulate the rsFC of the descending opioidergic pathway and reward/motivation system and blood inflammation markers. Elucidating the shared and unique mechanisms of different exercise modalities may facilitate the development of exercise-based interventions for chronic pain.

CLINICAL TRIAL REGISTRATION: ChiCTR-IOR-16009308.

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

KEYWORDS: descending pain modulation; dopamine; inflammation; knee osteoarthritis; mind–body intervention; physical exercise; resting-state functional connectivity

PMID: 31395306 DOI: 10.1016/j.bja.2019.06.017

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