Effects of electromagnetic fields on osteoarthritis.
Author: Wang T1, Xie W1, Ye W1, He C2
Affiliation:
1Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China.
2Department of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, China. Electronic address: hxkfhcq2015@126.com.
Conference/Journal: Biomed Pharmacother.
Date published: 2019 Aug 3
Other:
Volume ID: 118 , Pages: 109282 , Special Notes: doi: 10.1016/j.biopha.2019.109282. [Epub ahead of print] , Word Count: 160
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most common form of arthritis. The pathogenesis of OA is unclear, yet studies have shown that it is due to an imbalance between the synthesis and decomposition of chondrocytes, cell matrices and subchondral bone, which leads to the degeneration of articular cartilage. Currently, there are many therapies that can be used to treat OA, including the use of pulsed electromagnetic fields (PEMFs). PEMFs stimulate proliferation of chondrocytes and exert a protective effect on the catabolic environment. Furthermore, this technique is beneficial for subchondral trabecular bone microarchitecture and the prevention of subchondral bone loss, ultimately blocking the progression of OA. However, it is still unknown whether PEMFs could be used to treat OA in the clinic. Furthermore, the deeper signaling pathways underlying the mechanism by which PEMFs influence OA remain unclear.
Copyright © 2019. Published by Elsevier Masson SAS.
KEYWORDS: Chondrocytes; Extracellular matrix; Osteoarthritis; PEMFs; Subchondral bone loss
PMID: 31387007 DOI: 10.1016/j.biopha.2019.109282
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