Whole Body Vibration Training on Muscle Strength and Brain-Derived Neurotrophic Factor Levels in Elderly Woman With Knee Osteoarthritis: A Randomized Clinical Trial Study.

Author: Simão AP1, Mendonça VA2,3,4, Avelar NCP5, da Fonseca SF2,3, Santos JM2,3, de Oliveira ACC2,4, Tossige-Gomes R2,3, Ribeiro VGC2,3, Neves CDC2,3, Balthazar CH2,3, Leite HR2,3,4, Figueiredo PHS2,3,4, Bernardo-Filho M6, Lacerda ACR2,3,4
Author Information:
1Departamento de Fisioterapia, Universidade Federal de Alfenas (UNIFAL), Alfenas, Brazil.
2Centro Integrado de Pós-Graduação e Pesquisa em Saúde (CIPq-Saúde), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
3Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas (PMPGCF), Sociedade Brasileira de Fisiologia (SBFis), Butanta, Brazil.
4Programa de Pós-Graduação em Reabilitação e Desempenho Funcional (PPGReab), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
5Departamento de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Araranguá, Brazil.
6Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Conference/Journal: Front Physiol.
Date published: 2019 Jun 25
Other: Volume ID: 10 , Pages: 756 , Special Notes: doi: 10.3389/fphys.2019.00756. eCollection 2019. , Word Count: 284

Background: Osteoarthritis of the knee (kOA) is a chronic, progressive, degenerative health condition that contributes to the imbalance between the synthesis and destruction of articular cartilage. Recently, whole body vibration (WBV) training has been recommended as an effective alternative for strength training in elderly people, and various physiological effects are obtained in response to exercise performed on a vibratory platform, such as an increase in muscle activation and improved muscle performance. However, the effects of WBV particularly on the strength of the quadriceps muscle and neuronal plasticity are unknown. Objective: The aim of this study was to evaluate the effects of adding WBV to squat training on the isometric quadriceps muscle strength (IQMS) and the plasma levels of brain-derived neurotrophic factor (BDNF) in elderly woman with kOA. Methods: Fifteen elderly women ≥65 years of age with kOA were randomized into two interventions: (1) the vibration group (VG), in which participants performed squat exercise training in association with WBV or (2) the exercise group (EG), in which participants performed squat exercise training without vibration, for 12 weeks 3×/week. Results: Compared to the EG group, the VG group demonstrated a significantly greater delta (Δ) in IQMS values (IC95% 0.43-7.06; p ≤ 0.05) and in Δ BDNF plasma levels (IC95% -32.51 to 4.217; p ≤ 0.05) after the intervention period. There was an association between increase of Δ BDNF plasma levels and increase of Δ IQMS (β = 0.57; R 2 = 0.32; p = 0.03). Conclusion: The addition of WBV to squat exercise training improves lower limb muscle performance in elderly women with kOA. These findings suggest that the improvement in muscle performance is related to neuromuscular adaptations induced by WBV. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03918291.

KEYWORDS: brain-derived neurotrophic factor; muscle strength; osteoarthritis of knee; squat; whole body vibration

PMID: 31293437 PMCID: PMC6603338 DOI: 10.3389/fphys.2019.00756