Neurobiology of Resilience: Interface Between Mind and Body.
Author: Cathomas F1, Murrough JW2, Nestler EJ1, Han MH3, Russo SJ4
Affiliation:
1Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
2Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Mood and Anxiety Disorders Program, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
3Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pharmacological Sciences, Icahn School Medicine at Mount Sinai, New York, New York.
4Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York; Center for Affective Neuroscience of the Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: scott.russo@mssm.edu.
Conference/Journal: Biol Psychiatry.
Date published: 2019 Apr 17
Other:
Pages: S0006-3223(19)31279-X , Special Notes: doi: 10.1016/j.biopsych.2019.04.011. [Epub ahead of print] , Word Count: 185
Stress-related neuropsychiatric disorders, such as major depressive disorder and posttraumatic stress disorder, exact enormous socioeconomic and individual consequences. Resilience, the process of adaptation in the face of adversity, is an important concept that is enabling the field to understand individual differences in stress responses, with the hope of harnessing this information for the development of novel therapeutics that mimic the body's natural resilience mechanisms. This review provides an update on the current state of research of the neurobiological mechanisms of stress resilience. We focus on physiological and transcriptional adaptations of specific brain circuits, the role of cellular and humoral factors of the immune system, the gut microbiota, and changes at the interface between the brain and the periphery, the blood-brain barrier. We propose viewing resilience as a process that requires the integration of multiple central and peripheral systems and that elucidating the underlying neurobiological mechanisms will ultimately lead to novel therapeutic options.
Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
KEYWORDS: Blood-brain barrier; Gut microbiota; Inflammation; Major depressive disorder; Mesolimbic reward circuit; Posttraumatic stress disorder; Resilience; Stress
PMID: 31178098 DOI: 10.1016/j.biopsych.2019.04.011
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