Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and Treatment.
Author: Pavlov VA1,2, Chavan SS1,2, Tracey KJ1,2
Affiliation:
1Center for Biomedical Science and Bioelectronic Medicine, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York 11030.
2Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York 11550.
Conference/Journal: Cold Spring Harb Perspect Med.
Date published: 2019 May 28
Other:
Pages: a034140 , Special Notes: doi: 10.1101/cshperspect.a034140. [Epub ahead of print] , Word Count: 112
Bioelectronic medicine is an evolving field in which new insights into the regulatory role of the nervous system and new developments in bioelectronic technology result in novel approaches in disease diagnosis and treatment. Studies on the immunoregulatory function of the vagus nerve and the inflammatory reflex have a specific place in bioelectronic medicine. These studies recently led to clinical trials with bioelectronic vagus nerve stimulation in inflammatory diseases and other conditions. Here, we outline key findings from this preclinical and clinical research. We also point to other aspects and pillars of interdisciplinary research and technological developments in bioelectronic medicine.
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31138538 DOI: 10.1101/cshperspect.a034140
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