Vagus Nerve Stimulation and the Cardiovascular System.

Author: Capilupi MJ1, Kerath SM2, Becker LB1,2,3
1Department of Emergency Medicine, North Shore University Hospital, Northwell Health, Manhasset, New York 11030.
2Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York 11030.
3Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York 11549.
Conference/Journal: Cold Spring Harb Perspect Med.
Date published: 2019 May 20
Other: Pages: a034173 , Special Notes: doi: 10.1101/cshperspect.a034173. [Epub ahead of print] , Word Count: 135

The vagus nerve plays an important role in maintaining physiological homeostasis, which includes reflex pathways that regulate cardiac function. The link between vagus nerve activity and the high-frequency component of heart rate variability (HRV) has been well established, correlating with vagal tone. Recently, vagus nerve stimulation (VNS) has been investigated as a therapeutic for a multitude of diseases, such as treatment-resistant epilepsy, rheumatoid arthritis, Crohn's disease, and asthma. Because of the vagus nerve's innervation of the heart, VNS has been identified as a potential therapy for cardiovascular disorders, such as cardiac arrest, acute myocardial infarction, and stroke. Here, we review the current state of preclinical and clinical studies, as well as the potential application of VNS in relation to the cardiovascular system.

Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.

PMID: 31109966 DOI: 10.1101/cshperspect.a034173