Immunoresolvents signaling molecules at intersection between the brain and immune system.

Author: Dalli J1, Serhan CN2
Author Information:
1Lipid Mediator Unit, William Harvey Research Institute, Bart's and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom. Electronic address:
2Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Building for Transformative Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States.
Conference/Journal: Curr Opin Immunol.
Date published: 2018 Feb
Other: Volume ID: 50 , Pages: 48-54 , Special Notes: doi: 10.1016/j.coi.2017.10.007. Epub 2017 Nov 16. , Word Count: 149

Understanding mechanisms that control immunity is central in the quest to gain insights into the etiopathology of many of the diseases that afflict modern societies. New results implicate the nervous system as a central player in controlling many aspects of both the innate and adaptive arms of the immune response. Furthermore it is now well appreciated that a novel group of autacoids termed as specialized proresolving mediators, which are enzymatically produced from essential fatty acids, orchestrate the immune response promoting the termination of inflammation as well as tissue repair and regeneration. The present brief review discusses evidence for the crosstalk between the nervous system and leukocytes in regulating SPM production. We will also discuss the impact that this has on controlling tissue resolution tone and the resolution of both infectious and sterile inflammation.

Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

PMID: 29154174 PMCID: PMC5869050 DOI: 10.1016/j.coi.2017.10.007