Author: Feng F1, Yu S2, Wang Z3, Wang J4, Park J5, Wilson G5, Deng M6, Hu Y7, Yan B8, Kong J9
Affiliation:
1Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
2Department of Acupuncture & Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China; Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, MA, USA.
3Sichuan Integrative Medicine Hospital, Chengdu 610041, China.
4College of nursing, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
5Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, MA, USA.
6Department of mathematics and statistics, Sichuan Institute of Industrial Technology, Deyang 618005, Sichuan, China.
7Department of Acupuncture & Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
8Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address: ybh612003@163.com.
9Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, MA, USA. Electronic address: kongj@nmr.mgh.harvard.edu.
Conference/Journal: Neuroimage Clin.
Date published: 2019 Mar 4
Other:
Volume ID: 22 , Pages: 101745 , Special Notes: doi: 10.1016/j.nicl.2019.101745. [Epub ahead of print] , Word Count: 242
BACKGROUND: Primary insomnia (PI) is one of the most common complaints among the general population. Both non-pharmacological and pharmacological therapies have proven effective in treating primary insomnia. However, the underlying mechanism of treatment remains unclear, and no studies have compared the underlying mechanisms of different treatments.
METHODS: In this study, we investigated gray matter volume (GMV) and resting-state functional connectivity (rsFC) changes following both pharmacological and non-pharmacological treatments in patients with PI. A total of 67 PI patients were randomized into benzodiazepine treatment, cupping treatment, or a wait-list control group for 4 weeks. The Pittsburgh Sleep Quality Index (PSQI), gray matter volume (GMV), and resting-state functional connectivity (rsFC) of the hippocampus were measured at the beginning and end of the experiment.
RESULTS: We found 1) significantly decreased PSQI scores in the cupping and benzodiazepine treatment groups compared to the control group with no significant differences between the two treatment groups; 2) significant GMV increases in the cupping group compared to the control group at the right hippocampus after 4 weeks of treatment; 3) significantly increased rsFC between the right hippocampus and left rostral anterior cingulate cortex/medial prefrontal cortex (rACC/mPFC) in the two treatment groups, which was significantly associated with PSQI score decreases.
DISCUSSION: Our findings suggest that benzodiazepine and cupping may share a common mechanism to relieve the symptoms of patients with PI.
Copyright © 2019. Published by Elsevier Inc.
KEYWORDS: Gray matter volume; Hippocampus; Non-pharmacological therapy; Pharmacological therapy; Primary insomnia; Resting-state functional connectivity
PMID: 30878612 DOI: 10.1016/j.nicl.2019.101745
