Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation.
Author: Cotero V1, Fan Y1, Tsaava T2, Kressel AM2, Hancu I1, Fitzgerald P1, Wallace K1, Kaanumalle S1, Graf J1, Rigby W1, Kao TJ1, Roberts J1, Bhushan C1, Joel S1, Coleman TR2, Zanos S2, Tracey KJ2, Ashe J1, Chavan SS2, Puleo C3
Affiliation:
1GE Global Research Center, 1 Research Circle, Niskayuna, NY, 12309, USA.
2Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11020, USA.
3GE Global Research Center, 1 Research Circle, Niskayuna, NY, 12309, USA. puleo@ge.com.
Conference/Journal: Nat Commun.
Date published: 2019 Mar 12
Other:
Volume ID: 10 , Issue ID: 1 , Pages: 952 , Special Notes: doi: 10.1038/s41467-019-08750-9. , Word Count: 170
Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). Next, hepatic U/S stimulation is shown to modulate pathways that regulate blood glucose and is as effective as VNS in suppressing the hyperglycemic effect of endotoxin exposure. This response to hepatic U/S is only found when targeting specific sub-organ locations known to contain glucose sensory neurons, and both molecular (i.e. neurotransmitter concentration and cFOS expression) and neuroimaging results indicate US induced signaling to metabolism-related hypothalamic sub-nuclei. These data demonstrate that U/S stimulation within organs provides a new method for site-selective neuromodulation to regulate specific physiological functions.
PMID: 30862827 DOI: 10.1038/s41467-019-08750-9
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