Effect of transcranial pulsed electromagnetic fields (T-PEMF) on functional rate of force development and movement speed in persons with Parkinson's disease: A randomized clinical trial.
Author: Malling ASB1,2, Morberg BM1,2, Wermuth L1,2, Gredal O3, Bech P4, Jensen BR1
Affiliation:
1Department of Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
2Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
3The Danish Rehabilitation Centre for Neuromuscular Diseases, Taastrup, Denmark.
4Psychiatric Research Unit, Psychiatric Centre North Zealand, University of Copenhagen, Hillerød, Denmark.
Conference/Journal: PLoS One.
Date published: 2018 Sep 25
Other:
Volume ID: 13 , Issue ID: 9 , Pages: e0204478 , Special Notes: doi: 10.1371/journal.pone.0204478. eCollection 2018. , Word Count: 297
BACKGROUND: Parkinson's disease is caused by dopaminergic neurodegeneration resulting in motor impairments as slow movement speed and impaired balance and coordination. Pulsed electromagnetic fields are suggested to have neuroprotective effects, and could alleviate symptoms.
OBJECTIVE: To study 1) effects of 8-week daily transcranial pulsed electromagnetic field treatment on functional rate of force development and movement speed during two motor tasks with different levels of complexity, 2) if treatment effects depend on motor performance at baseline.
METHODS: Ninety-seven persons with Parkinson's disease were randomized to active transcranial pulsed electromagnetic field (squared bipolar 3 ms pulses, 50 Hz) or placebo treatment with homebased treatment 30 min/day for 8 weeks. Functional rate of force development and completion time of a sit-to-stand and a dynamic postural balance task were assessed pre and post intervention. Participants were sub-grouped in high- and low-performers according to their baseline motor performance level. Repeated measure ANOVAs were used.
RESULTS: Active treatment tended to improve rate of force development during chair rise more than placebo (P = 0.064). High-performers receiving active treatment improved rate of force development during chair rise more than high-performers receiving placebo treatment (P = 0.049, active/placebo: 11.9±1.1 to 12.5±1.9 BW/s ≈ 5% / 12.4±1.3 to 12.2±1.3 BW/s, no change). No other between-treatment-group or between-treatment-subgroup differences were found. Data on rate of force development of the dynamic balance task and completion times of both motor tasks improved but did not allow for between-treatment differentiation.
CONCLUSION: Treatment with transcranial pulsed electromagnetic fields was superior to placebo regarding functional rate of force development during chair rise among high-performers. Active treatment tended to increase functional rate of force development while placebo did not. Our results suggest that mildly affected persons with Parkinson's disease have a larger potential for neural rehabilitation than more severely affected persons and indicate that early treatment initiation may be beneficial.
PMID: 30252895 PMCID: PMC6155540 DOI: 10.1371/journal.pone.0204478
BACK
