Efficacy of Biophysical Energies on Healing of Diabetic Skin Wounds in Cell Studies and Animal Experimental Models: A Systematic Review.
Author: Kwan RL1, Lu S2, Choi HM3, Kloth LC4, Cheing GL5
Affiliation:
1Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. rachel.lc.kwan@connect.polyu.hk.
2Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. songlu.u.washington@gmail.com.
3Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. harry.choi@connect.polyu.hk.
4Department of Physical Therapy, College of Health Sciences, Marquette University, Milwaukee, WI 53201-1881, USA. luther.kloth@marquette.edu.
5Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. Gladys.Cheing@polyu.edu.hk.
Conference/Journal: Int J Mol Sci.
Date published: 2019 Jan 16
Other:
Volume ID: 20 , Issue ID: 2 , Special Notes: doi: 10.3390/ijms20020368. , Word Count: 198
We have systematically assessed published cell studies and animal experimental reports on the efficacy of selected biophysical energies (BPEs) in the treatment of diabetic foot ulcers. These BPEs include electrical stimulation (ES), pulsed electromagnetic field (PEMF), extracorporeal shockwave (ECSW), photo energies and ultrasound (US). Databases searched included CINAHL, MEDLINE and PubMed from 1966 to 2018. Studies reviewed include animal and cell studies on treatment with BPEs compared with sham, control or other BPEs. Information regarding the objective measures of tissue healing and data was extracted. Eighty-two studies were eventually selected for the critical appraisal: five on PEMF, four each on ES and ECSW, sixty-six for photo energies, and three about US. Based on the percentage of original wound size affected by the BPEs, both PEMF and low-level laser therapy (LLL) demonstrated a significant clinical benefit compared to the control or sham treatment, whereas the effect of US did not reveal a significance. Our results indicate potential benefits of selected BPEs in diabetic wound management. However, due to the heterogeneity of the current clinical trials, comprehensive studies using well-designed trials are warranted to confirm the results.
KEYWORDS: biophysical energies; cell; diabetes mellitus; experimental models; skin wounds; systematic review
PMID: 30654555 DOI: 10.3390/ijms20020368
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