Underlying Signaling Pathways and Therapeutic Applications of Pulsed Electromagnetic Fields in Bone Repair.

Author: Yuan J1, Xin F2, Jiang W1
1Department of Orthopedics, Tianjin First Center Hospital, Tianjin, China.
2Department of Respiration, Tianjin Institute of Respiratory Diseases, Tianjin Haihe Hospital, Tianjin Medical University, Tianjin, China.
Conference/Journal: Cell Physiol Biochem.
Date published: 2018 Apr 20
Other: Volume ID: 46 , Issue ID: 4 , Pages: 1581-1594 , Special Notes: doi: 10.1159/000489206. [Epub ahead of print] , Word Count: 180

Pulsed electromagnetic field (PEMF) stimulation, as a prospective, noninvasive, and safe physical therapy strategy to accelerate bone repair has received tremendous attention in recent decades. Physical PEMF stimulation initiates the signaling cascades, which effectively promote osteogenesis and angiogenesis in an orchestrated spatiotemporal manner and ultimately enhance the self-repair capability of bone tissues. Considerable research progresses have been made in exploring the underlying cellular and subcellular mechanisms of PEMF promotion effect in bone repair. Moreover, the promotion effect has shown strikingly positive benefits in the treatment of various skeletal diseases. However, many preclinical and clinical efficacy evaluation studies are still needed to make PEMFs more effective and extensive in clinical application. In this review, we briefly introduce the basic knowledge of PEMFs on bone repair, systematically elaborate several key signaling pathways involved in PEMFs-induced bone repair, and then discuss the therapeutic applications of PEMFs alone or in combination with other available therapies in bone repair, and evaluate the treatment effect by analyzing and summarizing recent literature.

KEYWORDS: Bone repair; Bone tissue engineering; Pulsed electromagnetic fields; Signaling pathways; Therapeutic applications

PMID: 29694967 DOI: 10.1159/000489206