Molecular and Functional Neuroscience in Immunity.
Author: Pavlov VA1, Chavan SS1, Tracey KJ1
Affiliation:
1Center for Biomedical Science and Center for Bioelectronic Medicine, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York 11030, USA; email: vpavlov@northwell.edu , schavan@northwell.edu , kjtracey@northwell.edu.
Conference/Journal: Annu Rev Immunol.
Date published: 2018 Apr 26
Other:
Volume ID: 36 , Pages: 783-812 , Special Notes: doi: 10.1146/annurev-immunol-042617-053158. , Word Count: 150
The nervous system regulates immunity and inflammation. The molecular detection of pathogen fragments, cytokines, and other immune molecules by sensory neurons generates immunoregulatory responses through efferent autonomic neuron signaling. The functional organization of this neural control is based on principles of reflex regulation. Reflexes involving the vagus nerve and other nerves have been therapeutically explored in models of inflammatory and autoimmune conditions, and recently in clinical settings. The brain integrates neuro-immune communication, and brain function is altered in diseases characterized by peripheral immune dysregulation and inflammation. Here we review the anatomical and molecular basis of the neural interface with immunity, focusing on peripheral neural control of immune functions and the role of the brain in the model of the immunological homunculus. Clinical advances stemming from this knowledge within the framework of bioelectronic medicine are also briefly outlined.
KEYWORDS: brain; cytokines; immunity; inflammation; nervous system; vagus nerve
PMID: 29677475 DOI: 10.1146/annurev-immunol-042617-053158
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