Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis
Author: Wayne PM1, Lee MS2, Novakowski J3, Osypiuk K3, Ligibel J4, Carlson LE5, Song R6
Affiliation:
1Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, 900 Commonwealth Avenue, 3rd floor, Boston, MA, 02215, USA. pwayne@partners.org.
2Clinical Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
3Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, 900 Commonwealth Avenue, 3rd floor, Boston, MA, 02215, USA.
4Zakim Center for Integrative Therapies and Healthy Living, Dana Farber Cancer Institute, Boston, MA, USA.
5Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
6College of Nursing, Chungnam National University, Daejeon, Republic of Korea.
Conference/Journal: J Cancer Surviv.
Date published: 2017 Dec 8
Other:
Special Notes: doi: 10.1007/s11764-017-0665-5. [Epub ahead of print] , Word Count: 270
PURPOSE: This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind-body exercises on symptoms and quality of life (QOL) in cancer survivors.
METHODS: A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges' g) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed.
RESULTS: Our search identified 22 studies, including 15 RCTs that evaluated 1283 participants in total, 75% women. RCTs evaluated breast (n = 7), prostate (n = 2), lymphoma (n = 1), lung (n = 1), or combined (n = 4) cancers. RCT comparison groups included active intervention (n = 7), usual care (n = 5), or both (n = 3). Duration of TCQ training ranged from 3 to 12 weeks. Methodological bias was low in 12 studies and high in 3 studies. TCQ was associated with significant improvement in fatigue (ES = - 0.53, p < 0.001), sleep difficulty (ES = - 0.49, p = 0.018), depression (ES = - 0.27, p = 0.001), and overall QOL (ES = 0.33, p = 0.004); a statistically non-significant trend was observed for pain (ES = - 0.38, p = 0.136). Random effects models were used for meta-analysis based on Q test and I 2 criteria. Funnel plots suggest some degree of publication bias. Findings in non-randomized studies largely paralleled meta-analysis results.
CONCLUSIONS: Larger and methodologically sound trials with longer follow-up periods and appropriate comparison groups are needed before definitive conclusions can be drawn, and cancer- and symptom-specific recommendations can be made.
IMPLICATIONS FOR CANCER SURVIVORS: TCQ shows promise in addressing cancer-related symptoms and QOL in cancer survivors.
KEYWORDS: Cancer; Fatigue; Meta-analysis; Qigong; Quality of life; Tai Chi
PMID: 29222705 DOI: 10.1007/s11764-017-0665-5
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