The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study.

Author: Meesters A1, den Bosch-Meevissen YMCI2, Weijzen CAH3, Buurman WA4, Losen M4, Schepers J5, Thissen MRTM6,7, Alberts HJEM2, Schalkwijk CG8, Peters ML2
Affiliation:
1Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. astrid.meesters@maastrichtuniversity.nl.
2Department of Clinical Psychological Science, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
3Department of Family Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
4Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
5Department of Methodology and Statistics, Faculty of Psychology and Neuroscience, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
6Department of Dermatology, Maastricht University Medical Centre+, P. Debyelaan 25, 6202 AZ, Maastricht, The Netherlands.
7GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre+, Universiteitssingel 40, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
8Department of Internal Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Conference/Journal: J Behav Med.
Date published: 2017 Nov 20
Other: Special Notes: doi: 10.1007/s10865-017-9901-8. [Epub ahead of print] , Word Count: 222

Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Pre- and post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might have beneficial effects on early stages of wound healing. Trial Registration NTR3652, http://www.trialregister.nl.

KEYWORDS: Cytokine; Growth factor; Inflammation; Intervention; Mindfulness; Wound healing

PMID: 29159589 DOI: 10.1007/s10865-017-9901-8

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