Low-intensity pulsed ultrasound improves behavioral and histological outcomes after experimental traumatic brain injury.
Author: Su WS1, Wu CH2, Chen SF3,4, Yang FY5,6
Affiliation:
1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
2Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
3Departments of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan. szufuchen@yahoo.com.tw.
4Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan. szufuchen@yahoo.com.tw.
5Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan. fyyang@ym.edu.tw.
6Biophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan. fyyang@ym.edu.tw.
Conference/Journal: Sci Rep.
Date published: 2017 Nov 14
Other:
Volume ID: 7 , Issue ID: 1 , Pages: 15524 , Special Notes: doi: 10.1038/s41598-017-15916-2. , Word Count: 177
The purpose of this study was to investigate the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on behavioral and histological outcomes in a mouse model of traumatic brain injury (TBI). Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured region daily for a period of 4 weeks. The effects of LIPUS on edema were observed by MR imaging in the mouse brain at 1 and 4 days following TBI. Brain water content, blood-brain barrier permeability, histology analysis, and behavioral studies were performed to assess the effects of LIPUS. Two-way analysis of variance and Student t test were used for statistical analyses, with a significant level of 0.05. Treatment with LIPUS significantly attenuated brain edema, blood-brain barrier permeability, and neuronal degeneration beginning at day 1. Compared with the TBI group, LIPUS also significantly improved functional recovery and reduced contusion volumes up to post-injury day 28. Post-injury LIPUS treatment reduced brain edema and improved behavioral and histological outcomes following TBI. The neuroprotective effects of LIPUS may be a promising new technique for treating TBI.
PMID: 29138458 DOI: 10.1038/s41598-017-15916-2
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