Effects of pulsed electromagnetic fields on postmenopausal osteoporosis.

Author: Zhu S1,2,3, He H1, Zhang C1,2, Wang H1,2, Gao C1,2, Yu X3, He C1,2
1Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
2Rehabilitation Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, P. R. China.
3Laboratory of Endocrinology and Metabolism, Department of Endocrinology, National Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, P. R. China.
Conference/Journal: Bioelectromagnetics.
Date published: 2017 Jun 30
Other: Special Notes: doi: 10.1002/bem.22065. [Epub ahead of print] , Word Count: 180

Postmenopausal osteoporosis (PMOP) is considered to be a well-defined subject that has caused high morbidity and mortality. In elderly women diagnosed with PMOP, low bone mass and fragile bone strength have been proven to significantly increase risk of fragility fractures. Currently, various anabolic and anti-resorptive therapies have been employed in an attempt to retain healthy bone mass and strength. Pulsed electromagnetic fields (PEMFs), first applied in treating patients with delayed fracture healing and nonunions, may turn out to be another potential and effective therapy for PMOP. PEMFs can enhance osteoblastogenesis and inhibit osteoclastogenesis, thus contributing to an increase in bone mass and strength. However, accurate mechanisms of the positive effects of PEMFs on PMOP remain to be further elucidated. This review attempts to summarize recent advances of PEMFs in treating PMOP based on clinical trials, and animal and cellular studies. Possible mechanisms are also introduced, and the future possibility of application of PEMFs on PMOP are further explored and discussed. Bioelectromagnetics. 2017;9999:XX-XX. © 2017 Wiley Periodicals, Inc.

© 2017 Wiley Periodicals, Inc.

KEYWORDS: PEMFs; PMOP; bone cells; bone homeostasis; bone quality

PMID: 28665487 DOI: 10.1002/bem.22065