Author: Shadyab AH1, LaMonte MJ2, Kooperberg C3, Reiner AP4, Carty CL5, Manini TM6, Hou L7, Di C3, Macera CA8, Gallo LC9, Shaffer RA8, Jain S10, LaCroix AZ11
Affiliation:
1Division of Epidemiology, Family Medicine and Public Health, University of California, San Diego School of Medicine, 9500 Gilman Drive #0725, La Jolla, CA 92093, USA. Electronic address: ahshadya@ucsd.edu.
2Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY 14228, USA.
3Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA.
4Department of Epidemiology, University of Washington, Seattle, WA 98105, USA.
5Division of Biostatistics and Study Methodology, Center for Translational Science, George Washington University and Children's National Medical Center, 2121 I St NW, Washington, D.C. 20052, USA.
6Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32611, USA.
7Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 420 E Superior St., Chicago, IL 60611, USA.
8Division of Epidemiology, San Diego State University Graduate School of Public Health, 5500 Campanile Drive, San Diego, CA 92182, USA.
9Department of Psychology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA.
10Division of Biostatistics and Bioinformatics, Family Medicine and Public Health, University of California, San Diego School of Medicine, 9500 Gilman Drive #0725, La Jolla, CA 92093, USA.
11Division of Epidemiology, Family Medicine and Public Health, University of California, San Diego School of Medicine, 9500 Gilman Drive #0725, La Jolla, CA 92093, USA.
Conference/Journal: Exp Gerontol.
Date published: 2017 May 25
Other:
Pages: S0531-5565(16)30468-5 , Special Notes: doi: 10.1016/j.exger.2017.05.019. [Epub ahead of print] , Word Count: 246
BACKGROUND: Shortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults.
METHODS: In this cross-sectional study, we examined associations of various intensity levels of leisure-time physical activity with LTL among 1476 older white and African American women from the Women's Health Initiative Objective Physical Activity and Cardiovascular Health study. Self-reported physical activity was assessed by questionnaire, and LTL was measured by Southern blot. The association between physical activity and LTL was evaluated using multiple linear regression models adjusted for demographic characteristics, lifestyle behaviors, and health-related variables.
RESULTS: Women were on average aged 79.2 (standard deviation 6.7) years old. In the final model adjusted for age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was on average 110 (95% confidence interval, 20-190) base pairs longer among women in the highest (≥17.00MET-hours/week) compared with the lowest (<1.25MET-hours/week) level of total leisure-time physical activity (P for trend=0.02). Higher levels of moderate-to-vigorous physical activity (P for trend=0.04) and faster walking speed (P for trend=0.03) were also associated with longer LTL in the fully-adjusted models.
CONCLUSION: Older women participating in greater amounts of total leisure-time physical activity and moderate-to-vigorous physical activity had longer LTL.
Copyright © 2017. Published by Elsevier Inc.
KEYWORDS: Leukocyte telomere length; MVPA; Older adults; Physical activity; Walking; Women
PMID: 28552815 DOI: 10.1016/j.exger.2017.05.019
