Accumulative effects of indoor air pollution exposure on leukocyte telomere length among non-smokers.
Author: Lin N1, Mu X2, Wang G3, Ren Y1, Su S1, Li Z4, Wang B4, Tao S5
Affiliation:
1Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, PR China.
2Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, PR China.
3Intensive Care Unit, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, PR China.
4Institute of Reproductive and Child Health, Peking University, Key Laboratory of Reproductive Health, National Health and Family Planning Commission of the People's Republic of China, Beijing 100191, PR China.
5Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, PR China. Electronic address: taos@pku.edu.cn.
Conference/Journal: Environ Pollut.
Date published: 2017 Apr 24
Other:
Volume ID: 227 , Pages: 1-7 , Special Notes: doi: 10.1016/j.envpol.2017.04.054. [Epub ahead of print] , Word Count: 192
Indoor air pollution is an important environmental factor that contributes to the burden of various diseases. Long-term exposure to ambient air pollution is associated with telomere shortening. However, the association between chronic indoor air pollution from household fuel combustion and leukocyte telomere length has not been studied. In our study, 137 cancer-free non-smokers were recruited. Their exposure levels to indoor air pollution from 1985 to 2014 were assessed using a face-to-face interview questionnaire, and leukocyte telomere length (LTL) was measured using a monochrome multiplex quantitative PCR method. Accumulative exposure to solid fuel usage for cooking was negatively correlated with LTL. The LTL of residents who were exposed to solid fuel combustion for three decades (LTL = 0.70 ± 0.17) was significantly shorter than that of other populations. In addition, education and occupation were related to both exposure to solid fuel and LTL. Sociodemographic factors may play a mediating role in the correlation between leukocyte telomere length and environmental exposure to indoor air pollution. In conclusion, long-term exposure to indoor air pollution may cause LTL dysfunction.
Copyright © 2017 Elsevier Ltd. All rights reserved.
KEYWORDS: Accumulative effects; Indoor air pollution; Leukocyte telomere length; Main finding; Solid fuel combustion
PMID: 28448823 DOI: 10.1016/j.envpol.2017.04.054
BACK
