The differential spatiotemporal expression pattern of shelterin genes throughout lifespan.

Author: Wagner KD1,2, Ying Y1,3, Leong W3, Jiang J3, Hu X3, Chen Y3,4, Michiels JF1,5, Lu Y3,6, Gilson E1,3,7, Wagner N1,2, Ye J3,6,4
Affiliation:
1Université Côte d'Azur, CNRS, Inserm, Institut for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, Nice, France.
2Université Côte d'Azur, CNRS, Inserm, Institut Biology Valrose (iBV), Faculty of Medicine, Nice, France.
3International Laboratory in Hematology and Cancer, Shanghai Jiao Tong University School of Medicine/Ruijin Hospital/CNRS/Inserm/Nice University, Pôle Sino-Français de Recherche en Sciences du Vivant et Génomique, Shanghai Ruijin Hospital, Shanghai, 200025, P.R. China.
4State Key laboratory for Medical Genomics，Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
5Department of Pathology, CHU Nice, Nice, France.
6Shanghai Ruijin Hospital North, Shanghai, P.R. China.
7Department of Medical Genetics, CHU Nice, France.
Conference/Journal: Aging (Albany NY).
Date published: 2017 Apr 17
Other: Special Notes: doi: 10.18632/aging.101223. [Epub ahead of print] , Word Count: 133

Shelterin forms the core complex of telomere proteins and plays critical roles in protecting telomeres against unwanted activation of the DNA damage response and in Emaintaining telomere length homeostasis. Although shelterin expression is believed to be ubiquitous for stabilization of chromosomal ends. Evidences suggest that some shelterin subunits have tissue-specific functions. However, very little is known regarding how shelterin subunit gene expression is regulated during development and aging. Using two different animal models, the mouse and zebrafish, we reveal herein that shelterin subunits exhibit distinct spatial and temporal expression patterns that do not correlate with the proliferative status of the organ systems examined. Together, this work shows that the shelterin subunits exhibit distinct spatiotemporal expression patterns, suggesting important tissue-specific functions during development and aging.

KEYWORDS: brain aging; development; shelterin; telomere

PMID: 28437249 DOI: 10.18632/aging.101223

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