Author: Payne P1, Fiering S1, Leiter JC2, Zava DT3, Crane-Godreau MA1
1 Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth Lebanon, NH, USA.
2 Department of Molecular and System Biology, Geisel School of Medicine at Dartmouth Lebanon, NH, USA.
3 ZRT Laboratory Beaverton, OR, USA.
Conference/Journal: Front Hum Neurosci.
Date published: 2017 Feb 21
Other: Volume ID: 11 , Pages: 67 , Special Notes: doi: 10.3389/fnhum.2017.00067. eCollection 2017. , Word Count: 277
This single-arm non-randomized pilot study explores an intervention to improve the health of flight attendants (FA) exposed to second-hand cigarette smoke prior to the smoking ban on commercial airlines. This group exhibits an unusual pattern of long-term pulmonary dysfunction. We report on Phase I of a two-phase clinical trial; the second Phase will be a randomized controlled trial testing digital delivery of the intervention. Subjects were recruited in the Northeastern US; testing and intervention were administered in 4 major cities. The intervention involved 12 h of training in Meditative Movement practices. Based on recent research on the effects of nicotine on fear learning, and the influence of the autonomic nervous system on immune function, our hypothesis was that this training would improve autonomic function and thus benefit a range of health measures. Primary outcomes were the 6-min walk test and blood levels of C-reactive protein. Pulmonary, cardiovascular, autonomic, and affective measures were also taken. Fourteen participants completed the training and post-testing. There was a 53% decrease in high sensitivity C-Reactive Protein (p ≤ 0.05), a 7% reduction in systolic blood pressure (p ≤ 0.05), a 13% increase in the 6-min walk test (p ≤ 0.005), and significant positive changes in several other outcomes. These results tend to confirm the hypothesized benefits of MM training for this population, and indicate that autonomic function may be important in the etiology and treatment of their symptoms. No adverse effects were reported. This trial is registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT02612389/), and is supported by a grant from the Flight Attendant Medical Research Institute (FAMRI).
KEYWORDS: Qigong; autonomic nervous system; flight attendants; nicotine and fear learning; resilience; second-hand cigarette smoke; somatics; stress in first responders
PMID: 28270757 DOI: 10.3389/fnhum.2017.00067