Mesenchymal stem cells as therapeutic target of biophysical stimulation for the treatment of musculoskeletal disorders.
Author: Viganò M1,2, Sansone V1,3, d'Agostino MC4, Romeo P1, Perucca Orfei C1,5, de Girolamo L6
Affiliation:
1IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161, Milan, Italy.
2Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
3Department of Biomedical Science for Health, University of Milan, Milan, Italy.
4ESWT Center, Rehabilitation Department, Humanitas Research Hospital, Rozzano, Milan, Italy.
5Department of Drug Sciences, University of Pavia, Pavia, Italy.
6IRCCS Galeazzi Orthopaedic Institute, Via R. Galeazzi 4, 20161, Milan, Italy. laura.degirolamo@grupposandonato.it.
Conference/Journal: J Orthop Surg Res.
Date published: 2016 Dec 16
Other:
Volume ID: 11 , Issue ID: 1 , Pages: 163 , Word Count: 262
BACKGROUND: Musculoskeletal disorders are regarded as a major cause of worldwide morbidity and disability, and they result in huge costs for national health care systems. Traditional therapies frequently turned out to be poorly effective in treating bone, cartilage, and tendon disorders or joint degeneration. As a consequence, the development of novel biological therapies that can treat more effectively these conditions should be the highest priority in regenerative medicine. Mesenchymal stem cells (MSCs) represent one of the most promising tools in musculoskeletal tissue regenerative medicine, thanks to their proliferation and differentiation potential and their immunomodulatory and trophic ability. Indeed, MSC-based approaches have been proposed for the treatment of almost all orthopedic conditions, starting from different cell sources, alone or in combination with scaffolds and growth factors, and in one-step or two-step procedures. While all these approaches would require cell harvesting and transplantation, the possibility to stimulate the endogenous MSCs to enhance their tissue homeostasis activity represents a less-invasive and cost-effective therapeutic strategy. Nowadays, the role of tissue-specific resident stem cells as possible therapeutic target in degenerative pathologies is underinvestigated. Biophysical stimulations, and in particular extracorporeal shock waves treatment and pulsed electromagnetic fields, are able to induce proliferation and support differentiation of MSCs from different origins and affect their paracrine production of growth factors and cytokines.
SHORT CONCLUSIONS: The present review reports the attempts to exploit the resident stem cell potential in musculoskeletal pathologies, highlighting the role of MSCs as therapeutic target of currently applied biophysical treatments.
KEYWORDS: ESWT; Electromagnetic fields; Mesenchymal stem cells; PEMF; Pericytes; Shock waves
PMID: 27986082 DOI: 10.1186/s13018-016-0496-5
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