Adiponectin potentially contributes to the anti-depressive effects of Baduanjin Qigong exercise in women with chronic fatigue syndrome-like illness.

Author: S J1, Li A2, Ng SM1, T R3, Xu A4, Yao TJ5, Wang XM3, So KF2, L C3
1Centre on Behavioral Health, Faculty of Social Science, The University of Hong Kong, Hong Kong SAR, China.
2Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Guangdong Key Laboratory of Brain Function and Diseases, Jinan University, Guangzhou, China.
3Department of Social Work and Social Administration, Faculty of Social Science, The University of Hong Kong, Hong Kong Special AdministrationRegion (Hong Kong SAR), China.
4Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
5Department of Biostatistics, Harvard C.H. Chan School of Public Health, Cambridge, MA, USA.
Conference/Journal: Cell Transplant.
Date published: 2016 Dec 7
Other: Special Notes: doi: 10.3727/096368916X694238. [Epub ahead of print] , Word Count: 291

<p>Our recent study demonstrates that adiponectin signaling plays a significant role in mediating physical exercise-exerted effects on hippocampal neurogenesis and antidepression in mice. Whether the findings can be translated to humans remains unknown.</p><p>This study aimed to investigate the effects of Baduanjin Qigong exercise on adiponectin, and evaluate whether adiponectin is involved in the anti-depressive effects of Qigong exercise on chronic fatigue syndrome (CFS)-like illness.</p><p>This is a randomized, waitlist-controlled trial. One hundred and eight female participants were randomly assigned to either Qigong exercise or waitlist groups. Sixteen 1.5-hour Qigong lessons were conducted. Outcome measures were taken at three time points.</p><p>Baseline adiponectin levels were negatively associated with body weight, body mass index, waist circumference, hip circumference and waist/hip ratio in women with CFS-like illness. Compared with waitlist control, Qigong exercise significantly reduced anxiety and depressive symptoms, and significantly raised plasma adiponectin levels (median = 0.8 vs. -0.1, p < 0.05). More interestingly, increases in adiponectin level following Qigong exercise were associated with decreases in depression score for the Qigong group (r = - 0.38, p = 0.04). Moreover, adjusted linear regression analysis further identified Qigong exercise and change in adiponectin level as the significant factors accounting for reduction of depressive symptoms.</p><p>Baduanjin Qigong significantly increased adiponectin level in females with CFS-like illness. Decreases in depressive symptoms were associated with increases in adiponectin levels following Qigong exercise, indicating that the potential contribution of adiponectin to Qigong exercise-elicited anti-depressive effects in human subjects.</p&gt.

PMID: 27938498 DOI: 10.3727/096368916X694238