Neuroprotective Effect of Low Frequency-Pulsed Electromagnetic Fields in Ischemic Stroke.
Author: Urnukhsaikhan E1, Mishig-Ochir T2, Kim SC3, Park JK1, Seo YK4
Affiliation:
1Department of Medical Biotechnology, Dongguk University, Seoul, Republic of Korea.
2Department of Biophysics, National University of Mongolia, Ulaanbaatar, Mongolia.
3Graduate School of Bio and Information Technology, Hankyong National University, Anseong-si, Kyonggi-do, South Korea.
4Department of Medical Biotechnology, Dongguk University, Seoul, Republic of Korea. bioseo@dongguk.edu.
Conference/Journal: Appl Biochem Biotechnol.
Date published: 2016 Oct 19
Other:
Word Count: 148
Low frequency-pulsed electromagnetic fields (LF-PEMFs) affect many biological processes; however, the fundamental mechanisms responsible for these effects remain unclear. Our study aimed to investigate the effect of LF-PEMFs on neuroprotection after ischemic stroke. C57B6 mice were exposed to LF-PEMF (F = 60 Hz, Bm = 10 mT) after photothrombotic occlusion. We measured the BDNF/TrkB/Akt signaling pathway, pro-apoptotic and pro-survival protein and gene expressions, and the expression of inflammatory mediators and performed behavioral tests in both LF-PEMF-treated and untreated ischemic stroke mice. Our results showed that LF-PEMF treatment promotes activation of the BDNF/TrkB/Akt signaling pathway. Subsequently, pro-survival proteins were significantly increased, while pro-apoptotic proteins and inflammatory mediators were decreased in ischemic stroke mice after LF-PEMF treatment. The results demonstrated that LF-PEMF exposure has a neuroprotective effect after ischemic stroke in mice during the recovery process.
KEYWORDS: Apoptosis; BDNF; Inflammation; Ischemic stroke; LF-PEMF
PMID: 27761795 DOI: 10.1007/s12010-016-2289-z
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