Physical exercise and brain mitochondrial fitness: The possible role against alzheimer's disease.

Author: Bernardo TC1, Marques-Aleixo I1, Beleza J1, Oliveira PJ2, Ascensão A1, Magalhães J1
1CIAFEL - Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Portugal.
2CNC - Centre for Neuroscience and Cell Biology, UC-Biotech, Biocant Park, University of Coimbra, Portugal.
Conference/Journal: Brain Pathol.
Date published: 2016 Jun 21
Other: Special Notes: doi: 10.1111/bpa.12403. [Epub ahead of print] , Word Count: 143

Exercise is one of the most effective strategies to maintain a healthy body and mind, with particular beneficial effects of exercise on promoting brain plasticity, increasing cognition and reducing the risk of cognitive decline and dementia in later life. Moreover, the beneficial effects resulting from increased physical activity occur at different levels of cellular organization, mitochondria being preferential target organelles. The relevance of this review paper relies on the need to integrate the current knowledge of proposed mechanisms, focus mitochondria, to explain the protective effects of exercise that might underlie neuroplasticity and seeks to synthesize these data in the context of exploring exercise as a feasible intervention to delay cognitive impairment associated with neurodegenerative conditions, particularly Alzheimer disease. This article is protected by copyright. All rights reserved.

© 2016 International Society of Neuropathology.

KEYWORDS: Alzheimer's disease; Exercise; Mitochondria

PMID: 27328058 [PubMed - as supplied by publisher]