Effects of mindfulness-based therapy for patients with breast cancer: A systematic review and meta-analysis.

Author: Zhang J1, Xu R2, Wang B2, Wang J2
1School of Nursing, Gansu University of Chinese Medicine, Lanzhou 730000, China. Electronic address: junz870124@163.com.
2School of Nursing, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Conference/Journal: Complement Ther Med.
Date published: 2016 Jun
Other: Volume ID: 26 , Pages: 1-10 , Special Notes: doi: 10.1016/j.ctim.2016.02.012. Epub 2016 Feb 21. , Word Count: 296

OBJECTIVE: To quantify the effects of mindfulness-based therapy (MBT) on physical health, psychological health and quality of life (QOL) in patients with breast cancer.

METHOD: Studies were identified through a systematic search of six electronic databases. Randomized control trials (RCTs) examining the effects of MBT, versus a control group receiving no intervention on physical health, psychological health and QOL in breast cancer patients were included. Two authors independently assessed the methodological quality of included studies using a quality-scoring instrument developed by Jadad et al. and extracted relevant information according to a predesigned extraction form. Data was analysed using the Cochrane Collaboration's Revman5.1.

RESULT: Finally, seven studies involving 951 patients were included. While limited in power, the results of meta-analysis indicated a positive effect of MBT in reducing anxiety [SMD -0.31, 95% CI -0.46 to -0.16, P<0.0001], depression[SMD -1.13, 95% CI -1.85 to -0.41, P=0.002], fear of recurrence[SMD -0.71, 95% CI -1.05 to -0.38, P<0.0001], and fatigue[SMD -0.88, 95% CI -1.71 to -0.05, P=0.04] associated with breast cancer, and improving emotional well-being [SMD 0.39, 95% CI 0.19-0.58, P=0.0001], physical function[SMD 0.42, 95% CI 0.19-0.65, P=0.0004], and physical health [SMD 0.31, 95% CI 0.08-0.54, P=0.009] in these patients. Although the effects on stress, spirituality, pain and sleep were in the expected direction, they were not statistically significant (P>0.05). Moreover, there is limited evidence from a narrative synthesis that MBT can improve QOL of breast cancer patients.

CONCLUSION: The present data indicate that MBT is a promising adjunctive therapy for patients with breast cancer. Due to some methodological flaws in the literature, further well-designed RCTs with large sample sizes are needed to confirm these preliminary estimates of effectiveness.

Copyright © 2016 Elsevier Ltd. All rights reserved.

KEYWORDS: Breast cancer; Mental health; Meta-analysis; Mindfulness; Quality of life; Systematic review

PMID: 27261975 [PubMed - as supplied by publisher]