Author: Kaut O1, Brenig D1, Marek M1, Allert N2, Wüllner U3
1Department of Neurology, University of Bonn, 53105 Bonn, Germany.
2Neurological Rehabilitation Center, Godeshoehe, 53117 Bonn, Germany.
3Department of Neurology, University of Bonn, 53105 Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.
Conference/Journal: Parkinsons Dis.
Date published: 2016
Other: Volume ID: 2016 , Pages: 7948721 , Special Notes: doi: 10.1155/2016/7948721. Epub 2016 Jan 26. , Word Count: 201
Background. Postural instability in Parkinson's disease (PD) increases the risk of falls and is not improved by pharmacological therapy. Objective. We performed a double-blind, randomized sham-controlled study to test the effects of stochastic resonance (whole body vibration) therapy on postural stability in PD. Methods. Fifty-six PD participants were allocated to either experimental or sham groups. The experimental group received four series of vibration over eight days, with each series consisting of six stimulus trains of 60-second duration using a randomized whole body vibration. Participants allocated to the control group received a sham treatment. Results. Within-group analysis revealed that postural stability in the experimental group improved by 17.5% (p = 0.005) comparing experimental and sham groups. The between-group analysis of change after treatment comparing both groups also showed a significant improvement of postural stability (p = 0.03). Only in the within-group analysis several items were improved after Bonferroni correction, too, rigor 41.6% (p = 0.001), bradykinesia 23.7% (p = 0.001), tremor 30.8% (p = 0.006), and UPDRSIII sum score 23.9% (p = 0.000), but did not reach the level of significance in the between-group analysis. Conclusions. Stochastic resonance therapy significantly enhanced postural stability even in individuals with increased risk of falling. Thus it offers a potential supplementation to canonical treatments of PD.
PMID: 26925293 [PubMed] PMCID: PMC4746396 Free PMC Article