Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation.
Author: Su WS1, Tsai ML2, Huang SL1, Liu SH3,4, Yang FY1,5,6.
Affiliation:
1Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan. 2Department of Pediatrics, Cheng Hsin General Hospital, Taipei, Taiwan. 3Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan. 4Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan. 5Biophotonics and Molecular Imaging Research Center, National Yang-Ming University, Taipei, Taiwan. 6Biomedical Engineering Research and Development Center, National Yang-Ming University, Taipei, Taiwan. Abstract
Conference/Journal: Oncotarget.
Date published: 2015 Oct 16
Other:
Special Notes: doi: 10.18632/oncotarget.5978 , Word Count: 178
It has been shown that the blood-brain barrier (BBB) can be locally disrupted by focused ultrasound (FUS) in the presence of microbubbles (MB) while sustaining little damage to the brain tissue. Thus, the safety issue associated with FUS-induced BBB disruption (BBBD) needs to be investigated for future clinical applications. This study demonstrated the neuroprotective effects induced by low-intensity pulsed ultrasound (LIPUS) against brain injury in the sonicated brain. Rats subjected to a BBB disruption injury received LIPUS exposure for 5 min after FUS/MB application. Measurements of BBB permeability, brain water content, and histological analysis were then carried out to evaluate the effects of LIPUS. The permeability and time window of FUS-induced BBBD can be effectively modulated with LIPUS. LIPUS also significantly reduced brain edema, neuronal death, and apoptosis in the sonicated brain. Our results show that brain injury in the FUS-induced BBBD model could be ameliorated by LIPUS and that LIPUS may be proposed as a novel treatment modality for controllable release of drugs into the brain.
KEYWORDS:
blood-brain barrier; brain injury; edema; low intensity ultrasound; permeability
PMID: 26517350
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