Author: Acar AH1, Yolcu Ü2, Altındiş S3, Gül M4, Alan H2, Malkoç S5.
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Bezmialem Vakif University, Istanbul, Turkey. Electronic address: firstname.lastname@example.org. 2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Inonu University, Malatya, Turkey. 3Private practice, Kayseri, Turkey. 4Department of Histology and Embriology, Faculty of Medicine, Inonu University, Malatya, Turkey. 5Department of Orthodontics, Faculty of Dentistry, Inonu University, Malatya, Turkey.
Conference/Journal: Arch Oral Biol.
Date published: 2015 Oct 23
Other: Volume ID: 61 , Pages: 60-65 , Special Notes: doi: 10.1016/j.archoralbio.2015.10.011 , Word Count: 167
We evaluated the efficacy of low-level laser therapy (LLLT) and low-intensity pulsed ultrasound (LIPUS), alone and in combination, in triggering new bone formation.
Sixteen New Zealand white rabbits were given two calvarial defects by using a 6-mm trephine bur, then divided into four treatment groups: control, LLLT, LIPUS, and LLLT+LIPUS. The LLLT and LIPUS groups were treated three times a week for two weeks. The LLLT+LIPUS group received each treatment on the same day, 12h apart, three days a week for two weeks. The animals were sacrificed after three weeks.
LLLT and LIPUS, alone and in combination, enhanced new bone formation in comparison to the untreated controls after three weeks (P<0.05); the combined therapy did not produce an additive effect.
Our results demonstrate the efficacy of LLLT or LIPUS in triggering bone regeneration. Therapeutic dose and duration requires further study.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Bone regeneration; Calvarial defect; Low-intensity pulsed ultrasound; Low-level laser therapy; Rabbit