Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks.
Author: Doll A1, Hölzel BK2, Boucard CC3, Wohlschläger AM4, Sorg C5.
Affiliation:
1Department of Neuroradiology, Technische Universität München TUM Munich, Germany ; Department of Psychiatry, Technische Universität München TUM Munich, Germany ; TUM-Neuro Imaging Center of Klinikum Rechts der Isar, Technische Universität München TUM Munich, Germany ; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Germany. 2Department of Neuroradiology, Technische Universität München TUM Munich, Germany. 3TUM-Neuro Imaging Center of Klinikum Rechts der Isar, Technische Universität München TUM Munich, Germany ; Department of Neurology, Technische Universität München TUM Munich, Germany. 4Department of Neuroradiology, Technische Universität München TUM Munich, Germany ; TUM-Neuro Imaging Center of Klinikum Rechts der Isar, Technische Universität München TUM Munich, Germany ; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-University Munich, Germany ; Department of Neurology, Technische Universität München TUM Munich, Germany. 5Department of Neuroradiology, Technische Universität München TUM Munich, Germany ; Department of Psychiatry, Technische Universität München TUM Munich, Germany ; TUM-Neuro Imaging Center of Klinikum Rechts der Isar, Technische Universität München TUM Munich, Germany ; Department of Nuclear Medicine, Technische Universität München TUM Munich, Germany.
Conference/Journal: Front Hum Neurosci.
Date published: 2015 Aug 25
Other:
Volume ID: 9 , Pages: 461 , Special Notes: doi: 10.3389/fnhum.2015.00461 , Word Count: 183
Abstract
Mindfulness is attention to present moment experience without judgment. Mindfulness practice is associated with brain activity in areas overlapping with the default mode, salience, and central executive networks (DMN, SN, CEN). We hypothesized that intrinsic functional connectivity (iFC; i.e., synchronized ongoing activity) across these networks is associated with mindfulness scores. After 2 weeks of daily 20 min attention to breath training, healthy participants were assessed by mindfulness questionnaires and resting-state functional MRI. Independent component analysis (ICA) of imaging data revealed networks of interest, whose activity time series defined inter-network intrinsic functional connectivity (inter-iFC) by temporal correlation. Inter-iFC between subnetworks of the DMN and SN-and inter-iFC between subnetworks of the SN and left CEN at trend-was correlated with mindfulness scores. Additional control analyses about visual networks' inter-iFC support the specificity of our findings. Results provide evidence that mindfulness is associated with iFC between DMN and SN. Data suggest that ongoing interactions among central intrinsic brain networks link with the ability to attend to current experience without judgment.
KEYWORDS:
central executive network; connectivity; default network; fMRI; mindfulness; resting state; salience network
PMID: 26379526 [PubMed] PMCID: PMC4548211
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