Author: Dudinskaya EN1, Tkacheva ON2, Shestakova MV3, Brailova NV4, Strazhesko ID5, Akasheva DU6, Isaykina OY7, Sharashkina NV8, Kashtanova DA9, Boytsov SA10.
Affiliation:
1E Dudinskaya, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation katharina.gin@gmail.com. 2O Tkacheva, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 3M Shestakova, Diabetes Institute, Endocrinology Research Centre, Moscow, Russian Federation. 4N Brailova, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 5I Strazhesko, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 6D Akasheva, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 7O Isaykina, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 8N Sharashkina, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 9D Kashtanova, Research of Age and Age-associated Conditions, National Research Center for Preventive Medicine, Moscow, Russian Federation. 10S Boytsov, Head of Department of Cardiology and Molecular Genetics, National Research Centre for Preventive Medicine, Moscow, Russian Federation.
Conference/Journal: Endocr Connect.
Date published: 2015 Jun 1
Other:
Pages: EC-15-0041 , Word Count: 225
It is known that glucose disturbances contribute to micro- and macro vascular complications and vascular aging. Telomere length is considered to be a cellular aging biomarker. It is important to determine the telomere length role in vascular structural and functional changes in patients with diabetes mellitus. The cross-sectional observational study was conducted in a high-risk population from Moscow, Russia. 50 patients with diabetes and without clinical cardiovascular disease and 49 control group participants were included in the study. Glucose metabolism assessment tests, measuring intima-media complex thickness and determining the presence of atherosclerotic plaques, pulse wave velocity measurement, and telomere length measurement were administered to all participants. Vascular changes were more dramatic in patients with diabetes than in control group. And the telomeres were shorter in patients with diabetes. There were significant differences in the vascular wall condition among diabetes patients and no substantial differences in the arterial structure between groups with 'long' telomeres, however, there were statistically significant differences in the vascular wall condition between groups with 'short' telomeres. Vascular ageing signs were more prominent in patients with diabetes. However, despite diabetes, vascular changes in patients with 'long' telomeres were very modest and were similar to the vascular walls in healthy individuals. Thus, 'long' lymphocyte telomeres may have a protective effect on the vascular wall and may prevent vascular wall deterioration caused by glucose metabolism disorders.
PMID: 26034119
