Author: Bao Q1, Pan J2, Qi H3, Wang L4, Qian H4, Jiang F4, Shao Z4, Xu F4, Tao Z4, Ma Q4, Nelson P5, Hu X6.
Affiliation:
1Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University (IGZJU). 2Department of Endocrinology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Gastroenterology, Zhejiang University (IGZJU). 3Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA. 4Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. 5Clinical Biochemistry Group,Medizinische Klinik und Poliklinik IV, University of Munich, Schillerstrasse 42, D-80336 Munich, Germany. 6Department of Plastic and Reconstructive Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: huxueqing@zju.edu.cn.
Conference/Journal: Mol Cell Endocrinol.
Date published: 2014 Jul 16
Other:
Pages: S0303-7207(14)00209-3 , Word Count: 157
Aging represents an important health issue not only for the individual, but also for society in general. Burdens associated with aging are expanding as longevity increases. This has led to an enhanced focus on issues related to aging and age-related diseases. Until recently, anti-aging endocrine-therapy has been largely limited to hormone-replacement therapy (HRT) that is associated with multiple side effects, including an increased risk of cancer. This has greatly limited the application of HRT in anti-aging therapy. Recently, the focus of anti-aging research has expanded from endocrine signaling pathways to effects on regulatory gene networks. In this regard, the GHRH-GH-IGF-1/Insulin, TOR-S6K1,NAD+-Sirtuin, P53, Klotho and APOE pathways have been linked to processes associated with age-related diseases, including cancer, cardiovascular disease, diabetes, osteoporosis, and neurodegenerative diseases, all of which directly influence health in aging, and represent key targets in anti-aging therapy.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
KEYWORDS:
Age-related diseases; Aging; Endocrine; Gene
PMID: 25038521
