Tai chi improves oxidative stress response and DNA damage/repair in young sedentary females.
Author: Huang XY1, Eungpinichpong W2, Silsirivanit A3, Nakmareong S4, Wu XH5.
Affiliation:
1Department of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Thailand ; School of Physical Education, Gannan Normal University, China ; Back, Neck and Other Joint Pain Research Group, Khon Kaen University, Thailand. 2Department of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Thailand ; Back, Neck and Other Joint Pain Research Group, Khon Kaen University, Thailand. 3Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Thailand. 4Department of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Thailand. 5School of Science and Technology, Gannan Normal University, China.
Conference/Journal: J Phys Ther Sci.
Date published: 2014 Jun
Other:
Volume ID: 26 , Issue ID: 6 , Pages: 825-9 , Special Notes: doi: 10.1589/jpts.26.825. , Word Count: 220
[Purpose] This study was to examine the effects of 12 weeks of Tai Chi (TC) exercise on antioxidant capacity, and DNA damage/repair in young females who did not perform regular physical exercise. [Subjects and Methods] Ten female students from a Chinese university voluntarily participated in this program. All of them practiced the 24-form simplified Tai Chi, 5 times weekly, for 12 weeks. Plasma levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), glutathione (GSH), hydroxyl radical inhibiting capacity (OH·-IC), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and 8-oxoguanine DNA glycosylase (OGG1) were measured at 0, 8, and 12 weeks. Heart rate (HR) was monitored during the last set of the training session at 4, 8, and 12 weeks. [Results] Plasma SOD and OH·-IC levels were increased at 8 and 12 weeks compared to the baseline (0 weeks). Gpx and GSH levels did not change significantly throughout the study period. The plasma MDA level was decreased significantly at 8 weeks but not at 12 weeks compared to the baseline value. While the plasma 8-OHdG level did not change throughout the study period, the plasma OGG1 level was significantly increased at 8 and 12 weeks compared to the baseline value. [Conclusion] TC practice for 12 weeks efficiently improved the oxidative stress response in young females who did not perform regular physical exercise. The TC exercise also increased the DNA repairing capacity.
KEYWORDS:
DNA damage; Oxidative stress; Tai Chi
PMID: 25013276
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