The Correlation between Peripheral Leukocyte Telomere Length and Indicators of Cardiovascular Aging.
Author: Zhang WG1, Zhu SY2, Zhao DL1, Jiang SM1, Li J3, Li ZX1, Fu B1, Zhang M1, Li DG1, Bai XJ4, Cai GY1, Sun XF5, Chen XM1.
Affiliation:
1Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing, China. 2Department of Nephrology, The Second Affiliated Hospital of Nanchang Medical University, Nanchang, China. 3Department of Cardiovascular, Chinese PLA General Hospital, Beijing, China. 4Departments of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China. 5Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing, China. Electronic address: xmchen301@126.com.
Conference/Journal: Heart Lung Circ.
Date published: 2014 Jan 31
Other:
Pages: S1443-9506(14)00047-X , Special Notes: doi: 10.1016/j.hlc.2013.12.016 , Word Count: 241
OBJECTIVES:
To investigate the relationship between telomere length in peripheral blood white cells and cardiovascular function in a healthy, aging Han Chinese population.
METHODS:
In 2012, peripheral blood leukocytes were obtained from 139 healthy individuals in Beijing, China, and telomere restriction fragment (TRF) length was assayed using a digoxigenin-labeled hybridization probe in Southern blot assays. Indicators of cardiovascular function were also evaluated, including electrocardiograms (ECG), (RR, P, PR, QRS, ST and T intervals); blood pressure (BP), (SBP, DBP, PP, PPI); cardiovascular ultrasound (left ventricular ejection fraction, LVEF); mitral early and late diastolic peak flow velocity (MVE and MVA); and lipid indices (TC, TG, HDL, LDL, LCI). The relationships of these cardiovascular indictors to telomere length were evaluated.
RESULTS:
No correlations were found between telomere length and ECG, BP or lipid indices even after adjustment for age. Correlations were found between TFR length and some cardiovascular ultrasound indictors (D, MVEA, MVEDT, MVES, MVEL, MVEI, IMT), but these were not seen after adjusting for age.
CONCLUSIONS:
We did not find that leukocyte TFR length was associated with cardiovascular ultrasound indictors, ECG, BP, or lipid indices in this population of healthy Han Chinese individuals. Telomere length may serve as a genetic factor in biological aging.
Copyright © 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
KEYWORDS:
Blood pressure; Cardiovascular function; Cardiovascular ultrasound.; Electrocardiogram; Telomere length
PMID: 24881030
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