Toward a brain functional connectivity mapping modality by simultaneous imaging of coherent brainwaves.
Author: Kim K1, Lee SJ2, Kang CS2, Hwang SM2, Lee YH2, Yu KK2.
Affiliation:
1Center for Brain and Cognition Measurement, Korea Research Institute of Standards and Science (KRISS), Doryong-dong, Yuseong-gu, Daejeon 305-340, Republic of Korea. Electronic address: kwkim@kriss.re.kr. 2Center for Brain and Cognition Measurement, Korea Research Institute of Standards and Science (KRISS), Doryong-dong, Yuseong-gu, Daejeon 305-340, Republic of Korea.
Conference/Journal: Neuroimage.
Date published: 2014 Jan 26
Other:
Pages: S1053-8119(14)00051-2 , Special Notes: doi: 10.1016/j.neuroimage.2014.01.030 , Word Count: 173
Matching the proton-magnetic-resonance frequency to the frequency of a periodic neural oscillation (e.g., alpha or gamma band waves) by magnetic resonance imaging techniques, enables direct visualization of brain functional connectivity. Functional connectivity has been studied by analyzing the correlation between coherent neural oscillations in different areas of the brain. In electro- or magneto-encephalography, coherent source reconstruction in a source-space is very tricky due to power leaking from the correlation among the sources. For this reason, most studies have been limited to sensor-space analyses, which give doubtful results because of volume current mixing. The direct visualization of coherent brain oscillations can circumvent this problem. The feasibility of this idea was demonstrated by conducting phantom experiments with a SQUID-based, micro-Tesla NMR/MRI system. We introduce an experimental trick, an effective step-up of the measurement B-field in a pulse sequence, to decouple the magnetic resonance signal from the strong magneto-encephalographic signal at the same frequency.
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
Biomagnetic resonance, Brain functional connectivity, MRI, NMR, SQUID
PMID: 24473099
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