Oscillatory dynamics and place field maps reflect sequence and place memory processing in hippocampal ensembles under NMDA receptor control

Author: Cabral HO1, Vinck M2, Fouquet C3, Pennartz CM2, Rondi-Reig L3, Battaglia FP4.
Affiliation:
1SILS - Center for Neuroscience, Universiteit van Amsterdam, 1090GE Amsterdam, the Netherlands; Cognitive Sciences Center Amsterdam, Research Priority Program "Brain and Cognition," 1018WS Amsterdam, the Netherlands; NERF, 3001 Leuven, Belgium; Donders Institute for Brain Cognition and Behavior, Radboud Universiteit Nijmegen, 6500GL Nijmegen, the Netherlands. Electronic address: cabralhenrique@gmail.com. 2SILS - Center for Neuroscience, Universiteit van Amsterdam, 1090GE Amsterdam, the Netherlands; Cognitive Sciences Center Amsterdam, Research Priority Program "Brain and Cognition," 1018WS Amsterdam, the Netherlands. 3Sorbonne Universités, UPMC Univ Paris 06, UMR-S 8246, Neuroscience Paris Seine, Navigation Memory and Aging Team, F-75005 Paris, France; INSERM, UMR-S 1130, Neuroscience Paris Seine, Navigation Memory and Aging Team, F-75005 Paris, France; CNRS, UMR 8246, Neuroscience Paris Seine, Navigation Memory and Aging Team, F-75005 Paris, France. 4SILS - Center for Neuroscience, Universiteit van Amsterdam, 1090GE Amsterdam, the Netherlands; Cognitive Sciences Center Amsterdam, Research Priority Program "Brain and Cognition," 1018WS Amsterdam, the Netherlands; NERF, 3001 Leuven, Belgium; Donders Institute for Brain Cognition and Behavior, Radboud Universiteit Nijmegen, 6500GL Nijmegen, the Netherlands; VIB, 3000 Leuven, Belgium. Electronic address: f.battaglia@science.ru.nl.
Conference/Journal: Neuron
Date published: 2014 Jan
Other: Volume ID: 81 , Issue ID: 2 , Pages: 402-15 , Special Notes: doi: 10.1016/j.neuron.2013.11.010 , Word Count: 210

Place coding in the hippocampus requires flexible combination of sensory inputs (e.g., environmental and self-motion information) with memory of past events. We show that mouse CA1 hippocampal spatial representations may either be anchored to external landmarks (place memory) or reflect memorized sequences of cell assemblies depending on the behavioral strategy spontaneously selected. These computational modalities correspond to different CA1 dynamical states, as expressed by theta and low- and high-frequency gamma oscillations, when switching from place to sequence memory-based processing. These changes are consistent with a shift from entorhinal to CA3 input dominance on CA1. In mice with a deletion of forebrain NMDA receptors, the ability of place cells to maintain a map based on sequence memory is selectively impaired and oscillatory dynamics are correspondingly altered, suggesting that oscillations contribute to selecting behaviorally appropriate computations in the hippocampus and that NMDA receptors are crucial for this function.

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID:
24462101

Initial evidence is found that the brain has a 'tuning knob' that is actually influencing behavior. Brain circuits can tune into the frequency of other brain parts relevant at the time. The scientific magazine Neuron is publishing the results of researchers at Radboud University the Netherlands on January 22.

KEYWORDS brain wave network frequency default mode network

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