Regional reductions in sleep electroencephalography power in obstructive sleep apnea: a high-density EEG study.
Author: Jones SG1, Riedner BA1, Smith RF1, Ferrarelli F1, Tononi G1, Davidson RJ2, Benca RM1.
Affiliation:
1Department of Psychiatry. 2Department of Psychiatry ; Department of Psychology, University of Wisconsin-Madison, Madison, WI.
Conference/Journal: Sleep
Date published: 2014 Feb 1
Other:
Volume ID: 37 , Issue ID: 2 , Pages: 399-407 , Word Count: 294
STUDY OBJECTIVES:
Obstructive sleep apnea (OSA) is associated with significant alterations in neuronal integrity resulting from either hypoxemia and/or sleep loss. A large body of imaging research supports reductions in gray matter volume, alterations in white matter integrity and resting state activity, and functional abnormalities in response to cognitive challenge in various brain regions in patients with OSA. In this study, we used high-density electroencephalography (hdEEG), a functional imaging tool that could potentially be used during routine clinical care, to examine the regional distribution of neural activity in a non-clinical sample of untreated men and women with moderate/severe OSA.
DESIGN:
Sleep was recorded with 256-channel EEG in relatively healthy subjects with apnea-hypopnea index (AHI) > 10, as well as age-, sex-, and body mass index-matched controls selected from a research population initially recruited for a study on sleep and meditation.
SETTING:
Sleep laboratory. Patients or Participants: Nine subjects with AHI > 10 and nine matched controls.
INTERVENTIONS:
N/A.
MEASUREMENTS AND RESULTS:
Topographic analysis of hdEEG data revealed a broadband reduction in EEG power in a circumscribed region overlying the parietal cortex in OSA subjects. This parietal reduction in neural activity was present, to some extent, across all frequency bands in all stages and episodes of nonrapid eye movement sleep.
CONCLUSION:
This investigation suggests that regional deficits in electroencephalography (EEG) power generation may be a useful clinical marker for neural disruption in obstructive sleep apnea, and that high-density EEG may have the sensitivity to detect pathological cortical changes early in the disease process.
CITATION:
Jones SG; Riedner BA; Smith RF; Ferrarelli F; Tononi G; Davidson RJ; Benca RM. Regional reductions in sleep electroencephalography power in obstructive sleep apnea: a high-density EEG study. SLEEP 2014;37(2):399-407.
KEYWORDS:
Brain imaging, EEG, neural activity, obstructive sleep apnea
PMID: 24497668
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