Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress.
Author: Birch-Machin MA, Russell EV, Latimer JA.
Affiliation:
Department of Dermatological Sciences, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. m.a.birch-machin@ncl.ac.uk
Conference/Journal: Br J Dermatol.
Date published: 2013 Jul
Other:
Volume ID: 169 Suppl 2 , Pages: 9-14 , Special Notes: doi: 10.1111/bjd.12207 , Word Count: 163
The skin is regularly exposed to the harmful effects of sunlight, such as ultraviolet radiation (UVR), which leads to ageing effects as well as clinical precancerous lesions and skin cancer. The accumulation of mitochondrial DNA (mtDNA) damage has been strongly associated as an underlying cause of the general ageing process in tissues and mtDNA damage has been associated with cancer development in many tissues including human skin. This scenario is linked to the key roles of mitochondrial function and mtDNA both in terms of energy production and also oxidative stress production as well as a mediator of apoptosis. We and others have pioneered the use of mtDNA damage as a highly sensitive biomarker of UVR exposure and oxidative stress in human skin; furthermore, ageing-dependent mtDNA mutations can be accelerated by exposure to sunlight. In addition, this review will also highlight useful applications of mtDNA as a biomarker of UVR-induced oxidative stress including effects of antioxidants.
© 2013 The Authors. BJD © 2013 British Association of Dermatologists.
PMID: 23786615
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