Impact of an active lifestyle on cardiovascular autonomic modulation and oxidative stress in males with overweight and parental history of hypertension
Author: Mario Cesar Nascimento1,2, Ariane Viana1, Danielle da Silva Dias1,3, Fernando Dos Santos1,4, Simone Dal Corso1,5, Maria Cláudia Irigoyen4, Marcelle Paula-Ribeiro#6, Kátia De Angelis#7,8
Affiliation:
1 Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
2 State University of Santa Catarina (UDESC), Santa Catarina, Brazil.
3 Postgraduate Program in Physical Education, Federal University of Maranhão, São Luís, Brazil.
4 Heart Institute (InCor), University of São Paulo, Medical School, Sao Paulo, Brazil.
5 Respiratory Research@Alfred, Central Clinical School, Monash University, Melbourne, Australia.
6 Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil.
7 Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil. prof.kangelis@yahoo.com.br.
8 Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil. prof.kangelis@yahoo.com.br.
Conference/Journal: J Hum Hypertens
Date published: 2024 Jan 30
Other:
Special Notes: doi: 10.1038/s41371-024-00895-5. , Word Count: 243
Family history of hypertension is associated with early autonomic dysfunction and increased oxidative stress. These alterations have been found to be reinforced by the overweight factor. Conversely, an active lifestyle is effective in improving the mechanisms regulating blood pressure control. Hence, we ought to investigate the effects of an active lifestyle on the hemodynamic, autonomic and oxidative stress parameters in individuals carrying both family history of hypertension and overweight risk factors. Fifty-six normotensive males were divided into four groups: eutrophic offspring of normotensive parents (EN, n = 12), eutrophic and inactive with hypertensive parents (EH, n = 14), overweight and inactive with hypertensive parents (OH, n = 13), and overweight and physically active with hypertensive parents (OAH, n = 17). Cardiovascular autonomic modulation was assessed by heart rate (HRV) and blood pressure (BPV) variability indexes. Oxidative stress included pro/antioxidant markers and nitrite concentration. Inactive offspring of hypertensive parents (EH and OH) showed higher LFSBP (vs EN), an indicator of sympathetic outflow to the vasculature and reduced anti-oxidant activity (vs EN), while higher pro-oxidant markers were found exclusively in OH (vs EN and EH). Conversely, the OAH group showed bradycardia, higher vagally-mediated HFabs index (vs OH and EN), lower sympathovagal balance (vs OH) and preserved LFSBP. Yet, the OAH showed preserved pro/antioxidant markers and nitrite levels. Our findings indicates that overweight offspring of hypertensive parents with an active lifestyle have improved hemodynamic, cardiac autonomic modulation and oxidative stress parameters compared to their inactive peers.
PMID: 38291242 DOI: 10.1038/s41371-024-00895-5
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