Author: Rodriguez RM, Fernandez AF, Fraga MF.
Conference/Journal: Genes Cancer.
Date published: 2013 Mar
Other:
Volume ID: 4 , Issue ID: 3-4 , Pages: 105-11 , Special Notes: doi: 10.1177/1947601913479798. , Word Count: 76
Sirtuins play an essential role in the cellular response to environmental stress, promoting DNA repair, telomere stability, cell cycle arrest, cellular senescence, and apoptosis. Much attention has been given to the role of sirtuins in aging and cancer development; however, less is known about their role in stem cell regulation. This review focuses in this topic and discusses the possible implications in adult stem cell aging.
KEYWORDS:
aging, development, sirtuins, stem cells
PMID: 24020001 [PubMed] PMCID: PMC3764466