Author: Kniazeva IR, Ivanov VV, Bol'shakov MA, Zharkova LP, Kereia AV, Kutenkov OP, Rostov VV.
Conference/Journal: Radiats Biol Radioecol.
Date published: 2013 Mar-Apr
Other:
Volume ID: 53 , Issue ID: 2 , Pages: 183-90 , Special Notes: [Article in Russian] , Word Count: 116
The effect of repetitive pulsed X-ray (4 ns pulse duration, 300 kV accelerating voltage; 2.5 kA electron beam current) on the antioxidant enzyme activity in mouse liver mitochondria has been investigated. The mitochondrial suspension was exposed to single 4000 pulse X-ray radiation with repetition rates ranging between 10 and 22 pps (pulsed dose was 0.3-1.8 x 10(-6) Gy/pulse, the total absorbed dose following a single exposure was 7.2 x 10(-3) Gy). It was shown that a short-time exposure to X-ray radiation changes the antioxidant enzyme activity in mouse liver mitochondria. The greatest effect was observed in the changes of the activity of the metal-containing enzymes: superoxide dismutase and glutathione peroxidase. The effect depends on the pulse repetition frequency and radiation dose.
PMID: 23786032