Author: Collip D, Geschwind N, Peeters F, Myin-Germeys I, van Os J, Wichers M.
Affiliation: Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.
Conference/Journal: PLoS One.
Date published: 2013 Jun 27
Other:
Volume ID: 8 , Issue ID: 6 , Pages: e66747 , Word Count: 300
CONTEXT:
Paranoia embodies altered representation of the social environment, fuelling altered feelings of social acceptance leading to further mistrust. Mindfulness-based cognitive therapy (MBCT) may relieve paranoia and reduce its impact on social acceptance.
OBJECTIVE:
To determine whether MBCT alters momentary feeling of paranoia and social acceptance in daily life.
DESIGN:
Randomized controlled trial of daily-life repeated measures (up to 120 per participant) before and after allocation to MBCT or waiting list control.
PARTICIPANTS:
Volunteer sample of 130 eligible men and women with residual affective dysregulation after at least one episode of major depressive disorder.
INTERVENTIONS:
Eight weeks of MBCT in groups of 10-15 participants in addition to participants' usual treatment.
OUTCOME MEASURES:
Daily-life ratings of paranoia and social acceptance. This manuscript concerns additional analyses of the original trial; hypotheses were developed after data collection (focus initially on depressive symptoms) but before data analysis.
RESULTS:
Sixty-six participants were assigned to the waiting list control group and 64 to the MBCT intervention group, of whom 66 and 61 respectively were included in the per-protocol analyses. Intention-to-treat analyses revealed a significant group by time interaction in the model of momentary paranoia (b = -.18, p<0.001, d = -0.35) and social acceptance (b = .26, p<0.001, d = 0.41). Paranoia levels in the intervention group were significantly reduced (b = -.11, p<0.001) and feelings of social acceptance significantly increased (b = .18, p<0.001), whereas in the Control condition a significant increase in paranoia (b = .07, p = 0.008) and a decrease in social acceptance was apparent (b = -.09, p = 0.013). The detrimental effect of paranoia on social acceptance was significantly reduced in the MBCT, but not the control group (group by time interaction: b = .12, p = 0.022).
CONCLUSIONS:
MBCT confers a substantial benefit on subclinical paranoia and may interrupt the social processes that maintain and foster paranoia in individuals with residual affective dysregulation.
TRIAL REGISTRATION:
Netherlands Trial Register NTR1084.
PMID: 23826125